Science fiction assumes we can go anywhere.

What it is that fucks the astronauts up?

Gravity and not connected to the Earth’s electromagnetic resonance frequency, known as the Schumann frequency. 

Until we have suits that use a signal generator using the Schumann frequency and it also needs to keep us at Earth gravity, we will get fucked the fucked up trying to get off the rock.

All science fiction dealing with leaving Earth is total fucking fiction. 

Simple truth.